Bacteria's Pathway from Mouth to Brain

It's very reasonable to think that gum disease will only impact your gums, and therefore only cause issues within your mouth. But, surprisingly, the bacteria associated with chronic gum disease, Porphyromonas gingivalis (P. gingivalis), has been found in the brains of individuals with Alzheimer's disease.

At the University of Louisville School of Dentistry, researchers found more convincing evidence on the association between  P. gingivalis with the development of Alzheimer's disease. They also found that a molecular therapy designed to potentially attack bad pathogens involved in Alzheimer's disease is also linked with periodontitis, a more severe form of gum disease. When studying animals, it was found that P. gingivalis found orally ended up colonizing the brain and increased the production of amyloid beta plaques that are commonly found in people with Alzheimer's disease. In addition, it was found that P. gingivalis releases a toxic enzyme known as gingipains into the neurons of people affected by Alzheimer's disease. Interestly, the researchers designed a molecule to block the harmful gingipains, which led to less P. gingivalis within the brain, a blockage of the production of amyloid beta plaques, less neuroinflammation, and a protective effect against neurons within the hippocampus, which is the part of the brain that is involved with memory. The research team is working on further research and clinical trials to determine a causal relationship between P. gingivalis and morbidity of Alzheimer's disease.

To maintain a healthy body it is thus imperative that our mouths remain healthy as well. There has been strong evidence linking bacteria within the mouth that can cause inflammation and damage systemically throughout the body. Gum disease can be prevented by keeping routine good oral hygiene habits.

Feel free to contact Drs. Ali & Ali and the caring team at Wellesley Dental Group if you have any thoughts or concerns; they will be happy to answer your questions! Contact us today at 781-237-9071 or to set up an appointment and consultation.

Your little ones and teens are welcome to visit our pediatric dentist Dr. DerekDr. Emad is happy to help with your orthodontic needs. For wisdom teeth extractions or any other oral surgery needs Dr. Stephens would be more than willing to help.




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