January 31st, 2014
Scientists have recently created a method for replacing missing teeth through the use of bio-engineered material developed from a person’s own gum cells. Up until now, dentists have been using implant-based methods to accommodate tooth loss. However, with this new breakthrough in dental research, perhaps patients may be able to receive a biological tooth replacement down the road!
Professor Paul Sharpe, a specialist in craniofacial development and stem cell biology King’s College London, published his findings in the Journal of Dental Research and was excited to present studies showing promising results on creating of “bio-teeth,” which is the generation of immature teeth that are similar those found in embryo. Professor Sharpe believes that these can be transplanted into adults and eventually develop to become perfectly functioning teeth. The team’s research showed that these embryonic immature teeth can grow normally in the adult mouth and may potentially be used clinically.
So far, the researchers have been able to isolate epithelial cells derived adult human gum tissue taken from patients at the Dental Institute at King’s College London. They were grown in the lab and then combined with mice cells that were known to form teeth. Through transplanting, Professor Sharpe and his team were created hybrid human/mouse teeth that had formed dentine and enamel, along with viable roots. This research shows that these easily accessible epithelial cells may be a feasible source for creating the human bio-tooth. Professor Sharpe explains there is still some ways to go in the progress of creating bio-teeth. Still more research needs to be done in identifying adult sources of specific epithelial cells, which are cells that line the surfaces of structures throughout the body; these cells may be the key in forming bio-tooth. Currently, scientists have only been able to create viable teeth through the use of embryonic cells; it is important for more research to be done to look for ways to manipulate adult human cells to develop into tooth. With more effort dedicated to this field of research, researches may one day be able to make bio-teeth a reality in patients needing teeth replacement!
But for now, patients have the opportunity to receive implants, which have been a successful method in dentistry to replace teeth. Usually made from titanium, implants are placed within the bone; quite amazingly, the bone in the jaw accepts the new structure and the implant readily fuses with the bone. Dentists have been using this method for restoring a single tooth and even a group of teeth that could have gone missing due to significant tooth decay or fracture.
If you believe that you may be in need of dental implants, feel free to contact Drs. Ali & Ali and the caring team at Wellesley Dental Group; they will be happy to answer your questions! Contact us today at 781-237-9071 or email@example.com to set up an appointment and consultation.