University of Louisville School of Dentistry

Bacteria's Pathway from Mouth to Brain

February 9th, 2019

It's very reasonable to think that gum disease will only impact your gums, and therefore only cause issues within your mouth. But, surprisingly, the bacteria associated with chronic gum disease, Porphyromonas gingivalis (P. gingivalis), has been found in the brains of individuals with Alzheimer's disease.

At the University of Louisville School of Dentistry, researchers found more convincing evidence on the association between  P. gingivalis with the development of Alzheimer's disease. They also found that a molecular therapy designed to potentially attack bad pathogens involved in Alzheimer's disease is also linked with periodontitis, a more severe form of gum disease. When studying animals, it was found that P. gingivalis found orally ended up colonizing the brain and increased the production of amyloid beta plaques that are commonly found in people with Alzheimer's disease. In addition, it was found that P. gingivalis releases a toxic enzyme known as gingipains into the neurons of people affected by Alzheimer's disease. Interestly, the researchers designed a molecule to block the harmful gingipains, which led to less P. gingivalis within the brain, a blockage of the production of amyloid beta plaques, less neuroinflammation, and a protective effect against neurons within the hippocampus, which is the part of the brain that is involved with memory. The research team is working on further research and clinical trials to determine a causal relationship between P. gingivalis and morbidity of Alzheimer's disease.

To maintain a healthy body it is thus imperative that our mouths remain healthy as well. There has been strong evidence linking bacteria within the mouth that can cause inflammation and damage systemically throughout the body. Gum disease can be prevented by keeping routine good oral hygiene habits.

Feel free to contact Drs. Ali & Ali and the caring team at Wellesley Dental Group if you have any thoughts or concerns; they will be happy to answer your questions! Contact us today at 781-237-9071 or smile@wellesleydentalgroup.com to set up an appointment and consultation.

Your little ones and teens are welcome to visit our pediatric dentist Dr. DerekDr. Emad is happy to help with your orthodontic needs. For wisdom teeth extractions or any other oral surgery needs Dr. Stephens would be more than willing to help.

References:

https://www.sciencedaily.com/releases/2019/01/190123165002.htm

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Smoking Equals More Germs!

September 6th, 2016

quitting-smoking

We've all heard that our bodies are home to millions of germs. But, new research has found that smoking increases the risk of certain bacteria like Porphyromonas gingivalis from invading the mouth and battling the immune system.

Researcher David A. Scott, Ph.D., at the University of Louisville School of Dentistry  recently investigated how cigarettes promotes bacteria colonization and disrupts the immune system.

Also, research published in Tobacco Induced Diseases indicated that cigarette smoke and its chemical components increase biofilm formation by bacteria including Staphylococcus aureus, Streptococcus mutans, Klebsiella pneumonia and Pseudomonas aeruginosa. These biofilms contain several microbial communities and can stick to most surfaces like teeth, heart valves, and the respiratory tract. Biofilms make it hard for your body's immune system to function properly. Not to mention, biofilms can promote antibiotic resistance and infection. A common biofilm is dental plaque, which can result in gingivitis, or even periodontitis.

 

It is never too late to quit smoking! Each year there are approximately  6 million worldwide death related to tobacco use. Eliminating tobacco products can truly lead to a healthier mouth and body.

Feel free to contact Drs. Ali & Ali and their newest addition to the team, Dr. Zarah Ali, if you have any thoughts or concerns. The caring team at Wellesley Dental Group will be happy to answer your questions! Contact us today at 781-237-9071 or smile@wellesleydentalgroup.com to set up an appointment and consultation.

Your little ones and teens are welcome to visit our pediatric dentist Dr. VanDr. Emad is happy to help with your orthodontic needs. For wisdom teeth extractions or any other periodontal or oral surgery needs, Dr. Ghazi would be more than willing to help.

References:

https://www.sciencedaily.com/releases/2016/05/160531082619.htm

http://images.medicaldaily.com/sites/medicaldaily.com/files/styles/full/public/2015/06/22/quitting-smoking.jpg

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